Illumina BeadStation

The Platform is equipped with an Illumina iScan instrument coupled to the Autoloader2. Assays are robotized on Tecan Freedom EVO instruments to improve throughput and technical consistency. This complete benchtop solution for genetic analysis enables a wide range of sample throughput.

Applications

• Genotyping (GWAS)

  Illumina proposes a range of BeadArrays with various numbers of SNPs interrogated, depending on the requirements of the projects. After whole genome amplification, Infinium assays are used: amplified DNA is hybridized onto arrays containing oligonucleotides with 3’ end positioned directly adjacent or overlapping the SNP site. SNP detection is performed by single base extension using dual colored assays (details in Illumina website). Infinium products comprise BeadArrays covering up to 4.3 million of SNPs and numerous CNVs. Custom or semi-custom arrays can also be designed.

• Methylation analysis

  Illumina has developped a robust methylation profiling platform that provides quantitative methylation measurement at the single-CpG-site resolution. Thanks to the Infinium assays, up to 850’000 methylation sites can be analyzed at a time.