Who we are
The Genomics Platform of iGE3 and the University of Geneva provides consulting
and access to the state-of-the-art methods in genomic technologies.
These technologies enable whole genomes, exomes, transcriptomes as well as more targeted sequencing.
SNP analysis (Genome-Wide Association Studies), cytogenetics, DNA copy number profiling and DNA methylation is also proposed.
The Genomics Platform offers a complete solution from optimisation of experimental design to data analysis.
Experimental designRecommendations about samples preparation, replicates number, internal controls are given. Guidelines for the selection of the relevant technology depending on the project are provided.
ExperimentSamples processing is performed either by the user under full supervision of the Platform staff or by the Platform staff itself.
Data analysisDepending on the application, standardized or more specific analysis pipelines are applied. Data processing tools are developed by the bioinformatics staff and proposed to users. Tools for data visualization, biological interpretation, pathway and Gene Ontology are also proposed.
installed at the Platform
The Platform is recently equipped with the NovaSeq 6000 sequencer from Illumina. This powerful and cost-effective sequencer can generate up to 6 Tb in less than 2 days. It also allows to scale up and down the output, ideal for large studies as well as innovating projects requiring specific configurations.
Gene expression research & Digital Spatial Profiling
October 19, 2021
NanoString and the Genomics Platform will hold a workshop on October 19, 2021, at the CMU. The new GeoMX Digital Spatial Profiler that allows highly multiplexed spatial RNA and protein profiling will be presented. Updates on the nCounter system (available on the Platform) will be given. Pre Charna Dibner (Depts of Medicine and Cell Physiology and Metabolism) will also share her last NanoString data. More details in the flyer. Registration is required.
SARS-CoV-2 whole genome
SARS-CoV-2 whole genome sequencing is now available at the Platform. Library preparation is performed with the amplicon-based Paragon Genomics panel. Amplicon sequencing is done on the Illumina MiSeq (2 x 150 bp). Data analysis is proposed (up the lineage assignment).
The Laboratory of Virology of the Geneva University Hospitals (Prof. Laurent Kaiser) publishes the SARS-CoV-2 whole genome sequences found in 17 patients among the very first infected people in Switzerland. Details on these figures. See also worldwide data on Nextstrain website.